SDI2 is a unique tool that allows scientists to uncover precisely what’s happening at the solid-liquid interface during the dissolution process. It enables the accurate measurement of intrinsic dissolution and release rates using very small sample amounts in addition to monitoring the swelling, erosion and disintegration processes for a wide range of whole dosage forms.
Ideal for use from pre-formulation through to CMC and final dosage form selection, the SDi2 uses a powerful 4.2 megapixel ActiPixTM detector to capture both ultra-violet and visible light recordings of the dissolution process, as it happens. The SDi2 generates high-resolution 2-D videos that uncover how these dynamic processes take place in real time. The SDi2 combines a fully-integrated fluidics system with a choice of small scale or whole dosage form flow cells. This allows researchers to study a wide range of sample types across the drug development timeline.
SDI2 gives scientists the ability to...
Real-time UV and visible light intensities are captured by the built-in Actipix™ detector providing a detailed, spatial view of the dissolution process directly at the solid-solution interface; a view that is unattainable with conventional dissolution methods. The dual wavelength capability allows for the measurement of drug concentration and monitoring of the physical processes in a single ex-periment.
While all the imaging area is available for data processing, the most commonly used measurements and calculations are applied to the data by default for ease of use.
The small scale and whole dosage flow cells can be quickly and conveniently exchanged, making the system suitable for a wide range of pharmaceutical development applications.
Dissolution media can be automatically changed at a pre-defined time during any experiment, for example, from gastric to intestinal pH media. Built-in flushing and cleaning procedures make for ease of use and help avoid cross contamination in the flow through set-up.
Surface dissolution UV imaging for characterization of superdisintegrants and their impact on drug dissolution
Design and development of a novel diffusion cell for advanced UV imaging to characterise pharmaceutical formulations
Tailored on demand anti-coagulant dosing: An in vitro and in vivo evaluation of 3D printed purpose-designed oral dosage forms
Effect of preparation method on the surface properties and UV imaging of indomethacin solid dispersions
Development of a novel method utilising dissolution imaging for the measurement of swelling behaviour in hydrophilic matrices
UV imaging in pharmaceutical analysis
Dissolution enhancement of griseofulvin from griseofulvin-sodium dodecyl sulfate discs investigated by UV imaging
Application of UV Imaging in Formulation Development
Variable-focus microscopy and UV surface dissolution imaging as complementary techniques in intrinsic dissolution rate determination
Microenvironmental pH measurement during sodium naproxenate dissolution in acidic medium by UV/vis imaging
Simultaneous UV Imaging and Raman Spectroscopy for the Measurement of Solvent-Mediated Phase Transformations During Dissolution Testing
Detection of poor acid resistance of enteric coats using the SDI
AAPS Advanced imaging, detection and prediction of initial gel formation and swelling of hypromellose compacts
Direct imaging of the dissolution of salt forms of a carboxylic acid drug
Evaluation of in vitro tests to reduce animal testing in drug toxicology studies
Faster Dissolution Methods
Low Volume Dissolution Assays
The effect of dissolution media, torque and flow speed
AAPS Understanding drug release mechanisms of metformin using complementary in vitro dissolution tools
Visualising the release patterns of promethazine across microparticulate systems
Use of SDI to assess dissolution characteristics - John Comer (Pion)
Application of the SDI in Pharmaceuticals - Mei Wong (Pfizer)
Characteristics of Felodipine ‐ HPMCAS Solid Dispersions
Understanding drug release mechanisms from diclofenac tablets using the SDi2
Validation of the SDi2 intrinsic dissolution rate measurement
Using SDi2 to characterise swelling and drug release profiles
Biorelevant drug release of Metformin dosage forms using complementary in vitro tools
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