The first instrument designed specifically to assess the risk and performance of subcutaneously administered drugs including biologics, peptides and small molecules. It generates the same rank orders of bioavailability observed in humans.
While there is a strong ethical desire to reduce in vivo testing, scientists also report extremely poor correlation between animal models and human outcomes for subcutaneously administered drugs. Other issues with current testing protocols include the high cost of in vivo work and the site-to-site and patient-to-patient variability which affect the confidence in the data being able to accurately predict the bioavailability of biopharmaceuticals in humans.
Scissor changes all that by providing a way to successfully assess the performance and risk of biologics, peptides and small molecules in vitro.
Scissor is the first instrument designed to simulate the stress conditions and environmental transitions that a biopharmaceutical, peptide or small molecule drug experiences when injected into a subcutaneous environment. These include chemical stresses - such as buffer composition, pH change and loss of excipients - and physical stresses - such as temperature and pressure changes. With that considered, there are also non-specific interactions with extracellular matrix components and aggregation events to contend with upon injection. Pion Scissor is the only available instrument of its kind to consider these factors when testing the performance of a subcutaneous drug in vitro.
Pion’s Scissor is the first instrument of its type to offer:
Scissor’s sophisticated model of the subcutaneous space features an artificial extracellular matrix which when combined with the simulated interstitial fluid in the system, creates a perfect platform to correlate with the active environment of the human body.
Experiments are easy to execute thanks to Scissor’s uncomplicated design. Mining data is simple too, thanks to the intuitive software and Excel based data reports. Results can be easily manipulated and interpreted to enable meaningful data comparison.
"Simulating Biologic Post Injection Events Utilizing the Pion Scissor" Webinar
Considerations on the Controlled Release of Injectable Insulin Using Scissor (Subcutaneous Injection Site Simulator)
Extended Instrument Shut Down for Pion Scissor Storage Guidelines
Improving the outcomes of biopharmaceutical delivery via the subcutaneous route by understanding the chemical, physical and physiological properties of the subcutaneous injection site
A novel in vitro method to model the fate of subcutaneously administered biopharmaceuticals and associated formulation components
WEBINAR: In vitro measurement of drug bioavailability following subcutaneous injection
In vitro model for predicting bioavailability of subcutaneously injected monoclonal antibodies
Glatiramer acetate persists at the injection site and draining lymph nodes via electrostatically-induced aggregation
Scissor subcutaneous poster
Subcutaneously administered biopharmaceuticals
AN503 Investigation of subcutaneous monoclonal antibody formulations
AN502 IN vitro studt of subcutaneous injection of two insulin formulations
AN501 A novel in vitro model for subcutaneous injection
AN418 Using Scissor as a platform to analyze non-protein subcutaneous formulations
Pion's quick response time to our service needs keeps downtime to a minimum in our lab.