scissor.svg

Scissor

The first instrument designed specifically to assess the risk and performance of subcutaneously administered drugs including biologics, peptides and small molecules. It generates the same rank orders of bioavailability observed in humans.

Add to quote basket

Overview

While there is a strong ethical desire to reduce in vivo testing, scientists also report extremely poor correlation between animal models and human outcomes for subcutaneously administered drugs. Other issues with current testing protocols include the high cost of in vivo work and the site-to-site and patient-to-patient variability which affect the confidence in the data being able to accurately predict the bioavailability of biopharmaceuticals in humans.

Scissor changes all that by providing a way to successfully assess the performance and risk of biologics, peptides and small molecules in vitro.

Scissor is the first instrument designed to simulate the stress conditions and environmental transitions that a biopharmaceutical, peptide or small molecule drug experiences when injected into a subcutaneous environment. These include chemical stresses - such as buffer composition, pH change and loss of excipients - and physical stresses - such as temperature and pressure changes. With that considered, there are also non-specific interactions with extracellular matrix components and aggregation events to contend with upon injection. Pion Scissor is the only available instrument of its kind to consider these factors when testing the performance of a subcutaneous drug in vitro.

Applications

Pion’s Scissor is the first instrument of its type to offer:

  • Determine rank order of different formations
  • Monitoring of drug stability upon injection
  • Indication of precipitation/ aggregation events occurring In vivo
  • Generation of release profiles and % bioavailability through offline analysis
  • Optional automated sample collection
  • Accurate modelling of the behavior subcutaneously administered pharmaceutical drugs

Features

Correlation

Scissor’s sophisticated model of the subcutaneous space features an artificial extracellular matrix which when combined with the simulated interstitial fluid in the system, creates a perfect platform to correlate with the active environment of the human body.

Simplicity

Experiments are easy to execute thanks to Scissor’s uncomplicated design. Mining data is simple too, thanks to the intuitive software and Excel based data reports. Results can be easily manipulated and interpreted to enable meaningful data comparison. 

Resources

Improving the outcomes of biopharmaceutical delivery via the subcutaneous route by understanding the chemical, physical and physiological properties of the subcutaneous injection site

Login

A novel in vitro method to model the fate of subcutaneously administered biopharmaceuticals and associated formulation components

Login

WEBINAR: In vitro measurement of drug bioavailability following subcutaneous injection

Login

In vitro model for predicting bioavailability of subcutaneously injected monoclonal antibodies

Login

Glatiramer acetate persists at the injection site and draining lymph nodes via electrostatically-induced aggregation

Login

Scissor subcutaneous poster

Login

Subcutaneously administered biopharmaceuticals

Login

AN503 Investigation of subcutaneous monoclonal antibody formulations

Login

AN502 IN vitro studt of subcutaneous injection of two insulin formulations

Login

AN501 A novel in vitro model for subcutaneous injection

Login

AN418 Using Scissor as a platform to analyze non-protein subcutaneous formulations

Login

Scissor Brochure

Login

Consumables

Scissor Cartridge Pack - Standard (Pack of 5)

11401-0001

Add to quote basket

Scissor Cartridge Pack - Collagen (Pack of 5)

11401-0004

Add to quote basket

Scissor Cartridge Electrode

10485-0001

Add to quote basket

Scissor Chamber Electrode

10485-0002

Add to quote basket

Temperature Probe

10408-0001

Add to quote basket

Chamber In Tube

10307-0001

Add to quote basket

Chamber Out Tube

10307-0002

Add to quote basket

Chamber CO2 Tube

10307-0003

Add to quote basket

Manual Sampling Tube

10307-0004

Add to quote basket

Autosampling In Tube

10307-0005

Add to quote basket

Autosampling Out Tube

10307-0006

Add to quote basket

External CO2 Tube

10307-0007

Add to quote basket

Luer tube tip 38mm

10301-0020

Add to quote basket

Luer injection port

10301-0021

Add to quote basket

Luer tube tip 25mm

10301-0023

Add to quote basket

Buffer vials

10304-0001

Add to quote basket

Drip Tray

10305-0001

Add to quote basket

Sampling Pump

11015-0009

Add to quote basket
Analytical Services

Analytical Services

We can run your research for you.

Find out more

Products at a glance

Products at a glance

Check out the specifications and capabilities of Pion equipment.

Find out more

Analytical Services

Analytical Services

Our analysts run standard tests and assays for you on Pion equipment or serve as consultative partners.

Find out more

Resource Library

Resource Library

Latest citations of Pion instruments and services in industry white papers, webinars, videos, and case studies.

Find out more

Pion's quick response time to our service needs keeps downtime to a minimum in our lab.

QC Director
Tennessee

Close