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SCISSOR N3

The first instrument designed specifically to assess the risk and performance of subcutaneously administered drugs including biologics, peptides and small molecules. Scissor provides the ability to rank order release curves in a human bio-relevant setting for effective formulation screening and candidate selection during development.

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Overview

While there is a strong ethical desire to reduce in vivo testing, scientists also report extremely poor correlation between animal models and human outcomes for subcutaneously administered drugs. Other issues with current testing protocols include the high cost of in vivo work and the site-to-site and patient-to-patient variability which affect the confidence in the data being able to accurately predict the bioavailability of biopharmaceuticals in humans.

SCISSOR N3 changes all that by providing a way to successfully assess the performance and risk of biologics, peptides and small molecules in vitro.

SCISSOR N3 is the first instrument designed to simulate the stress conditions and environmental transitions that a biopharmaceutical, peptide or small molecule drug experiences when injected into a subcutaneous environment. These include chemical stresses - such as buffer composition, pH change and loss of excipients - and physical stresses - such as temperature and pressure changes. With that considered, there are also non-specific interactions with extracellular matrix components and aggregation events to contend with upon injection. Pion SCISSOR is the only available instrument of its kind to consider these factors when testing the performance of a subcutaneous drug in vitro.

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Applications

Pion’s SCISSOR N3 is the first instrument of its type to offer:

  • Determine rank order of different formations
  • Monitoring of drug stability upon injection
  • Indication of precipitation/ aggregation events occurring In vivo
  • Generation of release profiles and % bioavailability through offline analysis
  • Optional automated sample collection
  • Accurate modelling of the behavior subcutaneously administered pharmaceutical drugs

Features

Correlation

SCISSOR N3’s sophisticated model of the subcutaneous space features an artificial extracellular matrix which when combined with the simulated interstitial fluid in the system, creates a perfect platform to correlate with the active environment of the human body.

Simplicity

Experiments are easy to execute thanks to SCISSOR N3’s uncomplicated design. Mining data is simple too, thanks to the intuitive software and Excel based data reports. Results can be easily manipulated and interpreted to enable meaningful data comparison. 

Resources

"Exciting new development for our SCISSOR - ECM XR artificial extracellular matrix for extended-release studies"

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"Simulating Biologic Post Injection Events Utilizing the Pion Scissor" Webinar

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Considerations on the Controlled Release of Injectable Insulin Using Scissor (Subcutaneous Injection Site Simulator)

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Extended Instrument Shut Down for Pion Scissor Storage Guidelines

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Improving the outcomes of biopharmaceutical delivery via the subcutaneous route by understanding the chemical, physical and physiological properties of the subcutaneous injection site

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A novel in vitro method to model the fate of subcutaneously administered biopharmaceuticals and associated formulation components

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WEBINAR: In vitro measurement of drug bioavailability following subcutaneous injection

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In vitro model for predicting bioavailability of subcutaneously injected monoclonal antibodies

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Glatiramer acetate persists at the injection site and draining lymph nodes via electrostatically-induced aggregation

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Scissor subcutaneous poster

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Subcutaneously administered biopharmaceuticals

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AN503 Investigation of subcutaneous monoclonal antibody formulations

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AN502 IN vitro studt of subcutaneous injection of two insulin formulations

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AN501 A novel in vitro model for subcutaneous injection

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AN418 Using Scissor as a platform to analyze non-protein subcutaneous formulations

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Scissor Brochure

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Consumables

Scissor Cartridge Pack - Standard (Pack of 5)

11401-0001

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Scissor Cartridge Electrode

10485-0001

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Scissor Chamber Electrode

10485-0002

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Temperature Probe

10408-0001

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Chamber In Tube

10307-0001

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Chamber Out Tube

10307-0002

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Chamber CO2 Tube

10307-0003

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Manual Sampling Tube

10307-0004

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Autosampling In Tube

10307-0005

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Autosampling Out Tube

10307-0006

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External CO2 Tube

10307-0007

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Luer tube tip 38mm

10301-0020

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Luer injection port

10301-0021

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Luer tube tip 25mm

10301-0023

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Buffer vials

10304-0001

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Drip Tray

10305-0001

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Sampling Pump

11015-0009

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Analytical Services

Analytical Services

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Products at a glance

Products at a glance

Check out the specifications and capabilities of Pion equipment.

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Analytical Services

Analytical Services

Our analysts run standard tests and assays for you on Pion equipment or serve as consultative partners.

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Resource Library

Resource Library

Latest citations of Pion instruments and services in industry white papers, webinars, videos, and case studies.

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