Tuesday, 15th of September
8:15 – 8:45 Attendee Arrival
8:45 – 9:00 Introduction to Pion and personnel
9:00 – 10:15 Method Development Part 1: Getting started with the technology and basic considerations
10:15– 10:40 Break
10:40 – 11:25 Method Development Part 2: Advanced considerations
11:25 – 12:10 Interactive Group Discussion #1: Fiber Optic Method Development. Working with changing background and molar absorptivity
12:10 – 1:00 Lunch (provided)
1:00 – 1:30 User Case Study #1 TBD
1:30 – 2:00 Zero intercept Method: Principles and Applications of ZIM
Dual-component dissolution
Monitoring for spectral consistency
Solubility of nanoparticles
Amorphous solubility vs. new phase formation
2:00 – 2:30 Group Discussion #2: Practical aspects of ZIM method implementation
2:30 – 2:50 Break
2:50 – 3:30 Advanced Tools: Dissolution Curve Analysis
3:30 – 4:45 Group Discussion #3: Continuation of ZIM and Dissolution Curve Analysis hands on practice
4:45 – 5:15 Q&A
5:30 – 8:00 Group social hour with follow up dinner
Wednesday, 16th of September
8:15 – 8:45 Attendee Arrival
8:45 – 9:30 Tools for understanding drug behavior – overview of Pion technology
9:30 – 10:15 Towards in vivo predictive dissolution – flux measurements
10:15 – 10:35 Break
10:35 – 11:05 User Case Study #2: TBD
11:05 – 11:50 Flux measurements: Analytical work behind the scene
11:50 – 12:20 User Case Study #3: TBD
12:20 – 1:20 Lunch (provided)
1:20 – 2:05 Group Discussion #4 Data Review and Basic Troubleshooting
2:05 – 2:50 Advanced Features of AuPRO Version 6
Dealing with more than 2 components—multicomponent regression analysis
Scatter modelling—can we estimate particle size from the shape of baseline?
Creating Reports
Standards for nanoparticles and colloids
Automating flux calculations
2:50 – 3:30 Q&A and Roundtable