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inForm

inForm is a powerful tool that allows you to study solubility under conditions that mimic those found in the body and environment, while providing detailed bio-relevant dissolution and solubility data to help you make formulation decisions more efficiently.

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Overview

inForm gives you the ability to run pH-solubility profiles with in-situ measurement, using only small amounts of material. inForm also uses innovative methods such as biphasic dissolution and gradient pH adjustments to show how a drug would behave under biorelevant conditions. It can accommodate multiple dosage forms and sample types with a built-in ability to remove aliquots for off-line analysis. Notably, inForm measures solubility using the CheqSol method, which eliminates interference by suspended solids. The UV option also supports controlled supersaturation studies.

Applications

inForm is a versatile platform for the automated analysis of solutions,

  • Detailed biorelevant data to support understanding of the GI transit of APIs
  • Built-in assays, including dissolution, biphasic dissolution, pH-metric dissolution and lipolysis
  • The ability to study digestion of lipid-based formulations
  • Optional modification for customized installations.
  • pH-dependent solubility profiling

Features

Robotics

inForm has a fully automated X, Y and Z axis on both arms, allowing you to run complicated assays that would be challenging to set up manually.

Precision

inForm’s precision engineering ensures that solubility experiments are accurate and highly reproduci-ble. For example, assays are performed in solution, 20 – 80 mL; large enough for high-accuracy meas-urement but small enough to conserve reagents and samples.

Versatility

Solid samples can be powders, granules or whole dosage forms; liquids can be solutions, suspensions and low viscosity lipid-based formulations.

Relevance

inForm allows you to measure solubility across a wide range of pH values, with precise measurement and control at every stage.

Resources

Multi-lab intrinsic solubility measurement reproducibility in CheqSol and shake-flask methods

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Understanding the self-assembly process of industrially relevant co-crystals

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Approaches for measuring intestinal precipitation rates of oral drugs

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Approaches for measuring intestinal precipitation rates

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PODCAST: Precipitation Behaviour of Weakly Basic Compounds - Solubility and Dissolution Enhancement

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WEBINAR: Pion inForm - a new instrument for investigating solubility and dissolution

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The behaviour of drug formulations under biorelevant and biphasic conditions

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WEBINAR: In-vitro approaches for investigating intestinal precipitation of oral drugs

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In vitro methods to assess drug precipitation in the fasted small intestine - a PEARRL review

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The ‘‘GI dissolution’’ method: a low volume, in vitro apparatus for assessing the dissolution/precipitation behaviour of an active pharmaceutical ingredient under biorelevant conditions

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4‐case chart to classify supersaturation and precipitation behavior

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A DoE study to understand partition rate in a biphasic system

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Evaluation of in vitro tests to reduce animal testing in drug toxicology studies

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Faster Dissolution Methods

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Controlled supersaturation by the solvent quench method, with UV monitoring of precipitation

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Supersaturation time with CheqSol using different excipients AZ

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Supersaturation, phase separation and measurement of precipitation rates

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AAPS 2017 Supersaturation excipients poster KBox

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AAPS 2017 Supersaturation modelling poster KBox

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Biorelevant dissolution - the quest for simple in-vitro experiments

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In-situ pH change on a biphasic dissolution model in the presence of SIFs

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Physicochemical Studies of Triclosan

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Biphasic dissolution studies: Impact of concentration and particle size on partition rate

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Improvements in biphasic dissolution

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Biphasic dissolution studies of Aripiprazole

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Robert Taylor: Automated Measurements of Lipolysis, Supersaturation & Biphasic Dissolution

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Automated Measurements of Precipitation, Supersaturation and Biphasic Dissolution

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Biphasic Dissolution Case Study of Carvedilol

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Salts Dissolution

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A pH stat method to measure the dissolution rate of nano- and microparticle suspensions

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Biphasic Dissolution Studies

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BCS Class IV formulation: case study

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Triclosan: a PhysChem study

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AN405 Controlled supersaturation by solvent-quench

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AN404 Biorelevant dissolution with gradient pH adjustment

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AN403 GI lipolysis of lipid based drug formulations

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AN402 Controlled supersaturation assays for modelling intestinal precipitation

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AN401 Biphasic Dissolution

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Pion inForm Intrinsic Dissolution Rate of Ibuprofen and its Sodium Salt

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AN09 The Determination of Solubility - Pion CheqSol Explained

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AN08 Solubility and Supersaturation - A Brief Introduction

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AN07 the Pion GI Dissolution Assay

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inForm Brochure

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Consumables

Basket

00115-0178

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Silicon Rubber Disc for 3mm tablet - Pack of 10

00302-0007

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Silicon Rubber Disc for 6mm tablet - Pack of 10

00302-0008

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Silicon Rubber Disc for 8mm tablet - Pack of 10

00302-0009

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inFORM Vial

00304-0001

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T3 - 50 mL Syringe

00306-0001

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10ml syringe

00306-0002

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5ml syringe

00306-0003

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Cap Piercing Needle

00306-0010

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inFORM Capillary Assembly

00306-0020

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Deuterium Lamp

00409-0001

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inFORM Electrode

00485-0002

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Filling solution for inFORM Electrode

01402-0001

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inFORM Peltier Assembly

01015-0004

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5mm path length tip

00408-0004

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10mm path length tip

00408-0005

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20mm path length tip

00408-0006

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Silicon Rubber Disc for 3mm tablet - Pack of 10

00302-0007

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Silicon Rubber Disc for 6mm tablet - Pack of 10

00302-0008

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Silicon Rubber Disc for 8mm tablet - Pack of 10

00302-0009

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3mm Tablet Disc - Pack of 5

00115-0170

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6mm Tablet Disc - Pack of 5

00115-0171

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8mm Tablet Disc - Pack of 5

00115-0172

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Sirius Tablet Press

01202-0001

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Analytical Services

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Products at a glance

Products at a glance

Check out the specifications and capabilities of Pion equipment.

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Analytical Services

Analytical Services

Our analysts run standard tests and assays for you on Pion equipment or serve as consultative partners.

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Resource Library

Resource Library

Latest citations of Pion instruments and services in industry white papers, webinars, videos, and case studies.

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