inForm
inForm is a powerful tool that allows you to study solubility under conditions that mimic those found in the body and environment, while providing detailed bio-relevant dissolution and solubility data to help you make formulation decisions more efficiently.
Overview
inForm gives you the ability to run pH-solubility profiles with in-situ measurement, using only small amounts of material. inForm also uses innovative methods such as biphasic dissolution and gradient pH adjustments to show how a drug would behave under biorelevant conditions. It can accommodate multiple dosage forms and sample types with a built-in ability to remove aliquots for off-line analysis. Notably, inForm measures solubility using the CheqSol method, which eliminates interference by suspended solids. The UV option also supports controlled supersaturation studies.
Applications
inForm is a versatile platform for the automated analysis of solutions,
- Detailed biorelevant data to support understanding of the GI transit of APIs
- Built-in assays, including dissolution, biphasic dissolution, pH-metric dissolution and lipolysis
- The ability to study digestion of lipid-based formulations
- Optional modification for customized installations.
- pH-dependent solubility profiling
Features
Robotics
inForm has a fully automated X, Y and Z axis on both arms, allowing you to run complicated assays that would be challenging to set up manually.
Precision
inForm’s precision engineering ensures that solubility experiments are accurate and highly reproduci-ble. For example, assays are performed in solution, 20 – 80 mL; large enough for high-accuracy meas-urement but small enough to conserve reagents and samples.
Versatility
Solid samples can be powders, granules or whole dosage forms; liquids can be solutions, suspensions and low viscosity lipid-based formulations.
Relevance
inForm allows you to measure solubility across a wide range of pH values, with precise measurement and control at every stage.
Resources
Multi-lab intrinsic solubility measurement reproducibility in CheqSol and shake-flask methods
Understanding the self-assembly process of industrially relevant co-crystals
Approaches for measuring intestinal precipitation rates of oral drugs
Approaches for measuring intestinal precipitation rates
PODCAST: Precipitation Behaviour of Weakly Basic Compounds - Solubility and Dissolution Enhancement
The behaviour of drug formulations under biorelevant and biphasic conditions
WEBINAR: In-vitro approaches for investigating intestinal precipitation of oral drugs
In vitro methods to assess drug precipitation in the fasted small intestine - a PEARRL review
The ‘‘GI dissolution’’ method: a low volume, in vitro apparatus for assessing the dissolution/precipitation behaviour of an active pharmaceutical ingredient under biorelevant conditions
4‐case chart to classify supersaturation and precipitation behavior
A DoE study to understand partition rate in a biphasic system
Evaluation of in vitro tests to reduce animal testing in drug toxicology studies
Faster Dissolution Methods
Controlled supersaturation by the solvent quench method, with UV monitoring of precipitation
Supersaturation time with CheqSol using different excipients AZ
Supersaturation, phase separation and measurement of precipitation rates
AAPS 2017 Supersaturation excipients poster KBox
AAPS 2017 Supersaturation modelling poster KBox
Biorelevant dissolution - the quest for simple in-vitro experiments
In-situ pH change on a biphasic dissolution model in the presence of SIFs
Physicochemical Studies of Triclosan
Biphasic dissolution studies: Impact of concentration and particle size on partition rate
Improvements in biphasic dissolution
Biphasic dissolution studies of Aripiprazole
Robert Taylor: Automated Measurements of Lipolysis, Supersaturation & Biphasic Dissolution
Automated Measurements of Precipitation, Supersaturation and Biphasic Dissolution
Biphasic Dissolution Case Study of Carvedilol
Salts Dissolution
A pH stat method to measure the dissolution rate of nano- and microparticle suspensions
Biphasic Dissolution Studies
BCS Class IV formulation: case study
Triclosan: a PhysChem study
AN405 Controlled supersaturation by solvent-quench
AN404 Biorelevant dissolution with gradient pH adjustment
AN403 GI lipolysis of lipid based drug formulations
AN402 Controlled supersaturation assays for modelling intestinal precipitation
AN401 Biphasic Dissolution
Pion inForm Intrinsic Dissolution Rate of Ibuprofen and its Sodium Salt
AN09 The Determination of Solubility - Pion CheqSol Explained
AN08 Solubility and Supersaturation - A Brief Introduction
AN07 the Pion GI Dissolution Assay
inForm Brochure
WEBINAR: Pion inForm - a new instrument for investigating solubility and dissolution
Consumables
Basket
00115-0178
Silicon Rubber Disc for 3mm tablet - Pack of 10
00302-0007
Silicon Rubber Disc for 6mm tablet - Pack of 10
00302-0008
Silicon Rubber Disc for 8mm tablet - Pack of 10
00302-0009
inFORM Vial
00304-0001
T3 - 50 mL Syringe
00306-0001
10ml syringe
00306-0002
5ml syringe
00306-0003
Cap Piercing Needle
00306-0010
inFORM Capillary Assembly
00306-0020
Deuterium Lamp
00409-0001
inFORM Electrode
00485-0002
Filling solution for inFORM Electrode
01402-0001
inFORM Peltier Assembly
01015-0004
5mm path length tip
00408-0004
10mm path length tip
00408-0005
20mm path length tip
00408-0006
Silicon Rubber Disc for 3mm tablet - Pack of 10
00302-0007
Silicon Rubber Disc for 6mm tablet - Pack of 10
00302-0008
Silicon Rubber Disc for 8mm tablet - Pack of 10
00302-0009
3mm Tablet Disc - Pack of 5
00115-0170
6mm Tablet Disc - Pack of 5
00115-0171
8mm Tablet Disc - Pack of 5
00115-0172
Sirius Tablet Press
01202-0001
Analytical Services
Our analysts run standard tests and assays for you on Pion equipment or serve as consultative partners.
Resource Library
Latest citations of Pion instruments and services in industry white papers, webinars, videos, and case studies.
Pion's quick response time to our service needs keeps downtime to a minimum in our lab.
QC Director
Tennessee