inForm is a powerful tool that bridges the gap between research-based micro-scale dissolution and the compendial world. It allows for precise pH control and monitoring, enabling you to study dissolution under conditions that mimic in vivo conditions more closely that other systems.
Ten out of ten of the world’s top pharmaceutical companies use Pion’s revolutionary fiber optic technology for dissolution measurement.
inForm gives you the ability to run pH-solubility profiles with in-situ measurement, using only small amounts of material. inForm also uses innovative methods such as biphasic dissolution and gradient pH adjustments to show how a drug would behave under biorelevant conditions. It can accommodate multiple dosage forms and sample types with a built-in ability to remove aliquots for off-line analysis. Notably, inForm measures solubility using the CheqSol method, which eliminates interference by suspended solids. The UV option also supports controlled supersaturation studies.
inForm is a versatile platform for the automated analysis of solutions, offering:
inForm’s precision engineering ensures that solubility experiments are accurate and highly reproduci-ble. For example, assays are performed in solution, 20 – 80 mL; large enough for high-accuracy meas-urement but small enough to conserve reagents and samples.
Solid samples can be powders, granules or whole dosage forms; liquids can be solutions, suspensions and low viscosity lipid-based formulations.
inForm allows you to measure solubility across a wide range of pH values, with precise measurement and control at every stage.
Multi-lab intrinsic solubility measurement reproducibility in CheqSol and shake-flask methods
Understanding the self-assembly process of industrially relevant co-crystals
Approaches for measuring intestinal precipitation rates of oral drugs
Approaches for measuring intestinal precipitation rates
PODCAST: Precipitation Behaviour of Weakly Basic Compounds - Solubility and Dissolution Enhancement
The behaviour of drug formulations under biorelevant and biphasic conditions
WEBINAR: In-vitro approaches for investigating intestinal precipitation of oral drugs
In vitro methods to assess drug precipitation in the fasted small intestine - a PEARRL review
The ‘‘GI dissolution’’ method: a low volume, in vitro apparatus for assessing the dissolution/precipitation behaviour of an active pharmaceutical ingredient under biorelevant conditions
4‐case chart to classify supersaturation and precipitation behavior
A DoE study to understand partition rate in a biphasic system
Evaluation of in vitro tests to reduce animal testing in drug toxicology studies
Faster Dissolution Methods
Controlled supersaturation by the solvent quench method, with UV monitoring of precipitation
Supersaturation time with CheqSol using different excipients AZ
Supersaturation, phase separation and measurement of precipitation rates
AAPS 2017 Supersaturation excipients poster KBox
AAPS 2017 Supersaturation modelling poster KBox
Biorelevant dissolution - the quest for simple in-vitro experiments
In-situ pH change on a biphasic dissolution model in the presence of SIFs
Physicochemical Studies of Triclosan
Biphasic dissolution studies: Impact of concentration and particle size on partition rate
Improvements in biphasic dissolution
Biphasic dissolution studies of Aripiprazole
Robert Taylor: Automated Measurements of Lipolysis, Supersaturation & Biphasic Dissolution
Automated Measurements of Precipitation, Supersaturation and Biphasic Dissolution
Biphasic Dissolution Case Study of Carvedilol
A pH stat method to measure the dissolution rate of nano- and microparticle suspensions
Biphasic Dissolution Studies
BCS Class IV formulation: case study
Triclosan: a PhysChem study
AN405 Controlled supersaturation by solvent-quench
AN404 Biorelevant dissolution with gradient pH adjustment
AN403 GI lipolysis of lipid based drug formulations
AN402 Controlled supersaturation assays for modelling intestinal precipitation
AN401 Biphasic Dissolution
Pion inForm Intrinsic Dissolution Rate of Ibuprofen and its Sodium Salt
AN09 The Determination of Solubility - Pion CheqSol Explained
AN08 Solubility and Supersaturation - A Brief Introduction
AN07 the Pion GI Dissolution Assay
WEBINAR: Pion inForm - a new instrument for investigating solubility and dissolution
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