Biphasic Dissolution techniques can establish more accurate correlations between in-vitro and in-vivo outcomes than conventional dissolution methods alone. Inform’s fibre-optic technology can be highly effective in supporting biphasic dissolution studies.
Ten of the world’s top ten pharmaceutical companies use Pion’s fibre-optic technology to support biphasic dissolution measurement.
inForm supports biphasic dissolution techniques to discriminate the performance of different formulations of controlled-released substances. It can accommodate multiple dosage formats and the use of biphasic dissolution media (aqueous / octanol, for instance) adds a new perspective to release profiles.
In-situ fibre-optic measurement, along with the built-in ability to remove aliquots, helps ensure consistency of results.
inForm allows you to measure solubility within a biphasic dissolution medium.
inForm has a fully automated X, Y and Z axis on both arms, allowing you to run complicated assays that would be challenging to set up manually.
inForm’s precision engineering ensures that solubility experiments are accurate and highly reproducible. For example, assays are performed in solution, 20 – 80 mL; large enough for high-accuracy measurement but small enough to conserve reagents and samples.
Solid samples can be powders, granules or whole dosage forms; liquids can be solutions, suspensions and low viscosity lipid-based formulatio
Multi-lab intrinsic solubility measurement reproducibility in CheqSol and shake-flask methods
Understanding the self-assembly process of industrially relevant co-crystals
Approaches for measuring intestinal precipitation rates of oral drugs
Approaches for measuring intestinal precipitation rates
PODCAST: Precipitation Behaviour of Weakly Basic Compounds - Solubility and Dissolution Enhancement
WEBINAR: Pion inForm - a new instrument for investigating solubility and dissolution
The behaviour of drug formulations under biorelevant and biphasic conditions
WEBINAR: In-vitro approaches for investigating intestinal precipitation of oral drugs
In vitro methods to assess drug precipitation in the fasted small intestine - a PEARRL review
The ‘‘GI dissolution’’ method: a low volume, in vitro apparatus for assessing the dissolution/precipitation behaviour of an active pharmaceutical ingredient under biorelevant conditions
4‐case chart to classify supersaturation and precipitation behavior
A DoE study to understand partition rate in a biphasic system
Evaluation of in vitro tests to reduce animal testing in drug toxicology studies
Faster Dissolution Methods
Controlled supersaturation by the solvent quench method, with UV monitoring of precipitation
Supersaturation time with CheqSol using different excipients AZ
Supersaturation, phase separation and measurement of precipitation rates
AAPS 2017 Supersaturation excipients poster KBox
AAPS 2017 Supersaturation modelling poster KBox
Biorelevant dissolution - the quest for simple in-vitro experiments
In-situ pH change on a biphasic dissolution model in the presence of SIFs
Physicochemical Studies of Triclosan
Biphasic dissolution studies: Impact of concentration and particle size on partition rate
Improvements in biphasic dissolution
Biphasic dissolution studies of Aripiprazole
Robert Taylor: Automated Measurements of Lipolysis, Supersaturation & Biphasic Dissolution
Automated Measurements of Precipitation, Supersaturation and Biphasic Dissolution
Biphasic Dissolution Case Study of Carvedilol
A pH stat method to measure the dissolution rate of nano- and microparticle suspensions
Biphasic Dissolution Studies
BCS Class IV formulation: case study
Triclosan: a PhysChem study
AN405 Controlled supersaturation by solvent-quench
AN404 Biorelevant dissolution with gradient pH adjustment
AN403 GI lipolysis of lipid based drug formulations
AN402 Controlled supersaturation assays for modelling intestinal precipitation
AN401 Biphasic Dissolution
Pion inForm Intrinsic Dissolution Rate of Ibuprofen and its Sodium Salt
AN09 The Determination of Solubility - Pion CheqSol Explained
AN08 Solubility and Supersaturation - A Brief Introduction
AN07 the Pion GI Dissolution Assay
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