Resource Library

Pion is delighted to have Dr. Corinne Jankovsky from Boehringer Ingelheim present work she and her colleagues have done using small scale in vitro techniques as predictive tools for in vivo performance and how they have incorporated Pion technology to guide formulation design.

Join us as Imogen Knight, Biopharmaceutical Product Specialist at Pion Inc, provides examples of biologic post injection event simulations utilizing the Pion Scissor.

Small volume dissolution testing has been an integral part of the global drug development process for decades. Now, with the launch of the Pion MiniDISS Profiler, the industry has a dedicated platform to perform this type of testing. Please join us as Pion Product Manager, Ken Caldwell, describes this new product in detail.

Join Andrew Kennedy, Pion Analytical Services Scientist II, as he unlocks the unseen secrets of your dissolution studies, using the Pion SDi2 to image the dissolution processes occurring at the surface of your samples. Andrew obtained a Master's in Chemistry from the University of Warwick in 2017. He joined Pion in 2018 and has developed expertise in the Pion SDi2 and across the entire range of Pion’s analytical tools while carrying out a wide variety of analyses for our partners across the pharmaceutical industry.

Haotian Wang presents the flux measurements that incorporate absorption steps to better understand complex dissolution-absorption interplay in formulation development and generic drug evaluation. 

Dr. Rebeca Ruiz presents an overview of Pion's Analytical Services group and the ways we can help your pharmaceutical drug formulation and drug development.

Pion Chief Technical Officer - Europe, Karl Box, and Dr. Patrick O'Dwyer from the University of Cork, present applications in biphasic dissolution. 

Hydrophilic matrix systems can be found in a wide range of extended release pharmaceutical formulations. The main principle of these systems is that upon contact with water, the hydrophilic component swells to form a hydrated gel layer which controls drug release. The following work demonstrates an explorative study into the use of surface dissolution imaging and focus variation microscopy with hydrophilic polymers. This study investigated the surface properties of xanthan gum (XG), polyethylene oxide (PEO), and hypromellose (hydroxypropyl methylcellulose, HPMC) compacts with each of these three hydrophilic polymers from one of each classification of natural, semi-synthetic, or synthetic polymer using a focus variation instrument.

Computational approaches are increasingly utilised in development of bio-enabling formulations, including self-emulsifying drug delivery systems (SEDDS), facilitating early indicators of success. This study, co-authored by Pion, investigated if in silico predictions of drug solubility gain i.e. solubility ratios (SR), after dispersion of a SEDDS in biorelevant media could be predicted from drug properties.

A newly developed excipient, β-cyclodextrin-grafted chitosan (BCC), was mixed with insulin in both acetate and citrate buffer solutions. It was discovered that when these complexes were administered into the gastrointestinal tract, both complexes increased insulin absorption significantly, and that the former complex led to rapid absorption, whereas the latter complex delayed and sustained absorption.