Female scientist looking at resources

Resource Library

Pion experts keep you informed with precise, accessible resources on a range of topics. Browse below to see how to optimize your equipment and research methods. Alternatively filter by your interest area. In addition we are delighted to bring you published resources from reliable and relevant experts. Browse below for articles and features recommended by Pion or filter your search for specific applications, products, or formats.

Filter:

Reset

Product

Application

Format

ImageTitleSummary 
WEBINAR: How pKa Values are used in the Pharmaceutical Industry

We have previously shown you how we measure pKa. This follow on webinar will describe why pKa is considered such a critical measurement in drug discovery and development environments.

Login
WEBINAR: Understanding and Measuring pKa

This is our first pKa webinar. In it, we describe the origins of the measurement, the origins of the science we use for our measurement platform and show you some of the extremely accurate data generated by the Pion SiriusT3

Login
Webinar: AuPRO™ Version 6.0: New Powerful Tools for Pion’s Fiber Optic Users

An informational webinar from our Chief Scientific Officer, Konstantin Tsinman, on Pion's new software, AuPRO 6.0. This new version is Windows 10 compatible and will also enable fiber optic users with some other powerful tools.

Login
AuPRO Comparison Flyer

AuPRO 6.0 software now offers several features to enhance the analysis of your compounds, secure your system (Windows 10 Compatible), and make your sample process more efficient.

Login
Effect of preparation method on the surface properties and UV imaging of indomethacin solid dispersions

This work explores the use of UV imaging in solid dispersion systems.

Login
Development of a novel method utilising dissolution imaging for the measurement of swelling behaviour in hydrophilic matrices

This work for the first time aims at developing an appropriate testing imaging methodology using a surface dissolution imaging instrument (SDI2) for determining the swelling of whole compacts using hypromellose as a model hydrophilic matrix former.

Login
Studies on dissolution testing of the nifedipine gastrointestinal therapeutic system. I. Description of a two-phase in vitro dissolution test Studies on dissolution testing of the nifedipine gastrointestinal therapeutic system. I. Description of a two-phase in vitro dissolution test

The nifedipine gastrointestinal therapeutic system (GITS) incorporates a push–pull osmotic pump to release–in zero-order fashion–a finely-divided suspension of nifedipine, which must then undergo dissolution in the GI tract before the drug can be absorbed. Classical, differential (ALZA) and flow-through type dissolution methods adequately characterize the in vitro nifedipine suspension release rate from the nifedipine GITS: however, these methods fail to measure the in vitro dissolution rate of the suspended particles–a potentially significant shortcoming considering that nifedipine is poorly water-soluble

Login
Predicting in vivo absorption behavior of oral modified release dosage forms containing pH-dependent poorly soluble drugs using a novel pH-adjusted biphasic in vitro dissolution test Predicting in vivo absorption behavior of oral modified release dosage forms containing pH-dependent poorly soluble drugs using a novel pH-adjusted biphasic in vitro dissolution test

The focus of in vitro dissolution testing during early development of modified release (MR) formulations is to provide predictive estimates of drug release in respect to in vivo performance of a drug product. However, there are enormous challenges in MR drug development to establish proper dissolution conditions for a predictive test. To overcome limitations of dissolution testing at constant pH, a modified USP apparatus 2 was developed, combining biphasic dissolution with a pH-gradient in the aqueous dissolution medium

Login
Toward Biorelevant Dissolution: Application of a Biphasic Dissolution Model as a Discriminating Tool for HPMC Matrices Containing a Model BCS Class II Drug Toward Biorelevant Dissolution: Application of a Biphasic Dissolution Model as a Discriminating Tool for HPMC Matrices Containing a Model BCS Class II Drug

The potential of a biphasic dissolution system to assist with the analysis of controlled-release (CR), Biopharmaceutics Classification System (BCS) Class II pharmaceutical products has been investigated. Use of a biphasic dissolution medium (aqueous/octanol) provided sink conditions and afforded complete dissolution of nifedipine formulated in a CR matrix tablet while maintaining the dosage form in an aqueous environmen

Login
Overcoming sink limitations in dissolution testing:a review of traditional methods and the potential utility of biphasic systems Overcoming sink limitations in dissolution testing:a review of traditional methods and the potential utility of biphasic systems

The conventional dissolution test, particularly the USP apparatus I andII, remains an important tool in the armory of the pharmaceutical development sci-entist. For realistic dissolution characterization, sink conditions, where saturationsolubility of a drug in the dissolution medium is at least three times more than thedrug concentration, are critical

Login
Close