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Simultaneous in situ monitoring of free drug concentration and nanoparticles during dissolution testing of nanocrystalline and amorphous formulations Simultaneous in situ monitoring of free drug concentration and nanoparticles during dissolution testing of nanocrystalline and amorphous formulations

The goal of this study was to develop a method of de-convoluting the UV-Vis spectra measured in situ to not only obtain the concentration of free drug in the presence of light absorbing nanoparticles but also to quantify the
concentration of nanoparticles present in suspensions.interplay between dissolution, solubility and permeability

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From Traditional Dissolution to  In Vivo Predictive Flux Measurements From Traditional Dissolution to In Vivo Predictive Flux Measurements

The webinar introduces the use of in situ fiber optic technique for traditional dissolution monitoring as well as for in vivo predictive flux measurements that uncover the interplay between dissolution, solubility and permeability

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Prediction of Bioequivalence and Food Effect Using Flux- and Solubility-Based Methods Prediction of Bioequivalence and Food Effect Using Flux- and Solubility-Based Methods

Flux values could be ised as input parameters for biopharmaceutics modeling and simulations to estimate ford effect and bioequivalence. 

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Simultaneous Determination of Intrinsic Solubility Simultaneous Determination of Intrinsic Solubility and pK of Ionizable Pharmaceutical Compounds Simultaneous Determination of Intrinsic Solubility Simultaneous Determination of Intrinsic Solubility and pK of Ionizable Pharmaceutical Compounds

Simultaneous Determination of Intrinsic Solubility Simultaneous Determination of Intrinsic Solubility and pK of Ionizable Pharmaceutical Compounds Simultaneous Determination of Intrinsic Solubility and pK a of Ionizable Pharmaceutical Compounds a of Ionizable Pharmaceutical Compounds using UV Titrations

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Spectrophotometric pKa Determination of Ionizable Pharmaceuticals: Resolution of Molecules with Weak pH-Dependent Spectral Shift Spectrophotometric pKa Determination of Ionizable Pharmaceuticals: Resolution of Molecules with Weak pH-Dependent Spectral Shift

Spectrophotometric pKa Determination of Ionizable Pharmaceuticals: Resolution of Molecules with Weak pH-Dependent Spectral Shift

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Design and development of a novel diffusion cell for advanced UV imaging to characterise pharmaceutical formulations Design and development of a novel diffusion cell for advanced UV imaging to characterise pharmaceutical formulations

Permeation tests are conducted to study API release from semisolid formulations to predictin vivo performance. United States Pharmacopeia details the Franz cell diffusion based evaluation of a topical formulation In this method, a topical formulation is administered into a donor chamber and permeation or diffusion is evaluated by quantifying the concentration of the drug in the receptor chamber. 

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Multi-lab intrinsic solubility measurement reproducibility in CheqSol and shake-flask methods Multi-lab intrinsic solubility measurement reproducibility in CheqSol and shake-flask methods

 

This commentary compares 233 CheqSol intrinsic solubility values (log S0) reported in the Wiki-pS0 
database for 145 different druglike  molecules  to  the 838 log S0 values determined  mostly  by  
the  saturation  shake- flask (SSF) method for 124 of the molecules  from the CheqSol set. The 
range of log S0 spans from  -1.0 to g molar units), averaging at -3.8.                              
                                                          

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Biorelevant Flux Measurements And Prediction Of Fraction Absorbed For The Drug Products Of Poorly Soluble Compounds Biorelevant Flux Measurements And Prediction Of Fraction Absorbed For The Drug Products Of Poorly Soluble Compounds

It was demonstrated that Flux measurements provided more in-depth understanding of supersaturated concentartions than solute concentration measurements alone. 

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Tailored on demand anti-coagulant dosing: An in vitro and in vivo evaluation of 3D printed purpose-designed oral dosage forms Tailored on demand anti-coagulant dosing: An in vitro and in vivo evaluation of 3D printed purpose-designed oral dosage forms

Coumarin therapy has been associated with high levels of inter- and intra-individual variation in the required dose to reach a therapeutic anticoagulation outcome. Therefore, a dynamic system that is able to achieve accurate delivery of a warfarin dose is of significant importance.

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Combining biorelevant in vitro and in silico tools to simulate and better understand the in vivo performance of a nano-sized formulation of aprepitant in the fasted and fed states Combining biorelevant in vitro and in silico tools to simulate and better understand the in vivo performance of a nano-sized formulation of aprepitant in the fasted and fed states

When developing bio-enabling formulations, innovative tools are required to understand and predict in vivo performance and may facilitate approval by regulatory authorities.

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