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Pion experts keep you informed with precise, accessible resources on a range of topics. Browse below to see how to optimize your equipment and research methods. Alternatively filter by your interest area. In addition we are delighted to bring you published resources from reliable and relevant experts. Browse below for articles and features recommended by Pion or filter your search for specific applications, products, or formats.

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"SDi2: Unlocking the Secrets of Your Dissolution" Webinar "SDi2: Unlocking the Secrets of Your Dissolution" Webinar

Join Andrew Kennedy, Pion Analytical Services Scientist II, as he unlocks the unseen secrets of your dissolution studies, using the Pion SDi2 to image the dissolution processes occurring at the surface of your samples. Andrew obtained a Master's in Chemistry from the University of Warwick in 2017. He joined Pion in 2018 and has developed expertise in the Pion SDi2 and across the entire range of Pion’s analytical tools while carrying out a wide variety of analyses for our partners across the pharmaceutical industry.

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"Pion MacroFLUX for Predictive Dissolution Absorption Measurements" Webinar "Pion MacroFLUX for Predictive Dissolution Absorption Measurements" Webinar

Haotian Wang presents the flux measurements that incorporate absorption steps to better understand complex dissolution-absorption interplay in formulation development and generic drug evaluation. 

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"Pion's Analytical Services" Webinar "Pion's Analytical Services" Webinar

Dr. Rebeca Ruiz presents an overview of Pion's Analytical Services group and the ways we can help your pharmaceutical drug formulation and drug development.

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"Pion Biphasic Dissolution  PBPK Modelling and Lipolysis Assays" Webinar "Pion Biphasic Dissolution PBPK Modelling and Lipolysis Assays" Webinar

Pion Chief Technical Officer - Europe, Karl Box, and Dr. Patrick O'Dwyer from the University of Cork, present applications in biphasic dissolution. 

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Application of Focus Variation Microscopy and Dissolution Imaging in Understanding the Behaviour of Hydrophilic Matrices Application of Focus Variation Microscopy and Dissolution Imaging in Understanding the Behaviour of Hydrophilic Matrices

Hydrophilic matrix systems can be found in a wide range of extended release pharmaceutical formulations. The main principle of these systems is that upon contact with water, the hydrophilic component swells to form a hydrated gel layer which controls drug release. The following work demonstrates an explorative study into the use of surface dissolution imaging and focus variation microscopy with hydrophilic polymers. This study investigated the surface properties of xanthan gum (XG), polyethylene oxide (PEO), and hypromellose (hydroxypropyl methylcellulose, HPMC) compacts with each of these three hydrophilic polymers from one of each classification of natural, semi-synthetic, or synthetic polymer using a focus variation instrument.

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Applying Computational Predictions of Biorelevant Solubility Ratio Upon Self-Emulsifying Lipid-Based Formulations Dispersion to Predict Dose Number Applying Computational Predictions of Biorelevant Solubility Ratio Upon Self-Emulsifying Lipid-Based Formulations Dispersion to Predict Dose Number

Computational approaches are increasingly utilised in development of bio-enabling formulations, including self-emulsifying drug delivery systems (SEDDS), facilitating early indicators of success. This study, co-authored by Pion, investigated if in silico predictions of drug solubility gain i.e. solubility ratios (SR), after dispersion of a SEDDS in biorelevant media could be predicted from drug properties.

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Considerations on the Controlled Release of Injectable Insulin Using Scissor (Subcutaneous Injection Site Simulator) Considerations on the Controlled Release of Injectable Insulin Using Scissor (Subcutaneous Injection Site Simulator)

A newly developed excipient, β-cyclodextrin-grafted chitosan (BCC), was mixed with insulin in both acetate and citrate buffer solutions. It was discovered that when these complexes were administered into the gastrointestinal tract, both complexes increased insulin absorption significantly, and that the former complex led to rapid absorption, whereas the latter complex delayed and sustained absorption.

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miniDISS Profiler Video miniDISS Profiler Video

A video showing the miniDISS Profiler, a Rainbow in situ Fiber Optic UV monitoring system with the miniDT dissolution tester, designed for biorelevant media volumes. 

 

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Pion's Solutions for Pharma Pion's Solutions for Pharma

Discover our comprehensive solutions for the pharma industry.

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miniDISS Profiler Brochure miniDISS Profiler Brochure

New! miniDISS Profiler

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