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Applying Computational Predictions of Biorelevant Solubility Ratio Upon Self-Emulsifying Lipid-Based Formulations Dispersion to Predict Dose Number Applying Computational Predictions of Biorelevant Solubility Ratio Upon Self-Emulsifying Lipid-Based Formulations Dispersion to Predict Dose Number

Computational approaches are increasingly utilised in development of bio-enabling formulations, including self-emulsifying drug delivery systems (SEDDS), facilitating early indicators of success. This study, co-authored by Pion, investigated if in silico predictions of drug solubility gain i.e. solubility ratios (SR), after dispersion of a SEDDS in biorelevant media could be predicted from drug properties.

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Considerations on the Controlled Release of Injectable Insulin Using Scissor (Subcutaneous Injection Site Simulator) Considerations on the Controlled Release of Injectable Insulin Using Scissor (Subcutaneous Injection Site Simulator)

A newly developed excipient, β-cyclodextrin-grafted chitosan (BCC), was mixed with insulin in both acetate and citrate buffer solutions. It was discovered that when these complexes were administered into the gastrointestinal tract, both complexes increased insulin absorption significantly, and that the former complex led to rapid absorption, whereas the latter complex delayed and sustained absorption.

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miniDISS Profiler Video miniDISS Profiler Video

A video showing the miniDISS Profiler, a Rainbow in situ Fiber Optic UV monitoring system with the miniDT dissolution tester, designed for biorelevant media volumes. 

 

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Pion's Solutions for Pharma Pion's Solutions for Pharma

Discover our comprehensive solutions for the pharma industry.

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miniDISS Profiler Brochure miniDISS Profiler Brochure

New! miniDISS Profiler

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MicroDISS Profiler - an introduction MicroDISS Profiler - an introduction

A video introduction into MicroDISS Profiler™ instrument and its applications

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SiriusT3 Product Brochure SiriusT3 Product Brochure

Discover the benefits of using Pion's SiriusT3

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Extended Instrument Shut Down for Sirius T3 Storage Guidelines Extended Instrument Shut Down for Sirius T3 Storage Guidelines

Extended Instrument Shut Down for Pion SiriusT3  Storage Guidelines 

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Extended Instrument Shut Down for Pion Rainbow Storage Guidelines Extended Instrument Shut Down for Pion Rainbow Storage Guidelines

Extended Instrument Shut Down for Pion Rainbow Storage Guidelines

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Extended Instrument Shut Down for Pion PULSE Storage Guidelines Extended Instrument Shut Down for Pion PULSE Storage Guidelines

Extended Instrument Shut Down for Pion PULSE Storage Guidelines

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