Female scientist looking at resources

Resource Library

Pion experts keep you informed with precise, accessible resources on a range of topics. Browse below to see how to optimize your equipment and research methods. Alternatively filter by your interest area. In addition we are delighted to bring you published resources from reliable and relevant experts. Browse below for articles and features recommended by Pion or filter your search for specific applications, products, or formats.

Filter:

Reset

Product

Application

Format

ImageTitleSummary 
https://www.youtube.com/watch?v=NOHcE5iteHs&feature=youtu.be Introducing DissoPRO Version 3.5 – a powerful GMP ready fiber optic software solution

Introducing DissoPRO Version 3.5 – a powerful GMP ready fiber optic software solution

Login
Surface dissolution UV imaging for characterization of superdisintegrants and their impact on drug dissolution Surface dissolution UV imaging for characterization of superdisintegrants and their impact on drug dissolution

Superdisintegrants are a key excipient used in immediate release formulations to promote fast tablet disintegration, therefore understanding the impact of superdisintegrant variability on product performance is important. The current study examined the impact of superdisintegrant critical material attributes (viscosity for sodium starch glycolate (SSG), particle size distribution (PSD) for croscarmellose sodium (CCS)) on their performance (swelling) and on drug dissolution using surface dissolution UV imaging. Acidic and basic pharmacopoeia (compendial) media were used to assess the role of varying pH on superdisintegrant performance and its effect on drug dissolution

Login
Evaluating side‐by‐side diffusion models for studying drug supersaturation in an absorptive environment: a case example of fenofibrate and felodipine Evaluating side‐by‐side diffusion models for studying drug supersaturation in an absorptive environment: a case example of fenofibrate and felodipine

To test whether a side‐by‐side diffusion model is suitable for studying drug supersaturation in an absorptive environment.

Login
Diclofenac Prodrugs for Intra-articular Depot Injectables: In Vitro Hydrolysis and Species Variation Diclofenac Prodrugs for Intra-articular Depot Injectables: In Vitro Hydrolysis and Species Variation

Intra-articular depot injectables based on in situ suspension formation of ester prodrugs of nonsteroidal anti-inflammatory drugs are promising for management of joint pain. As candidates for this delivery approach, 5 diclofenac ester prodrugs comprising different imidazole-containing promoieties were synthesized and their physicochemical properties characterized. In vitro hydrolysis rates were investigated in buffer solutions, in 40% (v/v) human, equine, canine, and rat plasma, and in 80% (v/v) human and equine synovial fluid. Bioconversion of the prodrugs to diclofenac was found to be enzyme-mediated and follow pseudo-first-order kinetics. Large variations in hydrolysis rates were observed between species and between prodrugs, with prodrug half-lives in plasma from canine, rat, horse, and human of 3.44-141 min, 2.51-14 min, 0.58-1.31 min, and 0.23-1.70 min, respectively. Half-lives in human and equine synovial fluid were 1.6- to 28-fold larger than in plasma. The results highlight the significance of species and tissue variation in prodrug design and suggest that the horse may constitute a suitable model for testing the intra-articular depot approach. Two prodrug candidates appeared promising for future in vivo studies based on their rapid in vitro enzyme-mediated bioconversion to diclofenac and physiochemical characteristics.

Login
Release notes - DissoPro 3.5 Release notes - DissoPro 3.5

DissoPro 3.5 is now available with improved functionality to make administrative duties simpler, security setup more straight forward and data analysis more capable and flexible. Please see the release note for more detailed information.

Login
A video introduction into microDISS Profiler™ instrument and its applications A video introduction into microDISS Profiler™ instrument and its applications

An overview of Pions flagship product, the microDiss Profiler incorporating the Rainbow fiber optic system. 

Login
Probing the mechanism of bupivacaine drug release from multivesicular liposomes Probing the mechanism of bupivacaine drug release from multivesicular liposomes

Researchers from FDA use Pion’s MicroDISS Profiler to probe mechanism of the release kinetics of a drug from multivesicular liposomes

Login
Degree and Extent of Supersaturation of Amorphous Pharmaceuticals and Their Flux through Lipophilic Membrane Degree and Extent of Supersaturation of Amorphous Pharmaceuticals and Their Flux through Lipophilic Membrane

The goal of this study was to apply in situ concentration monitoring for quick assessment of degree and extent of supersaturation that can be achieved by amorphization of the drug. In addition the comparison of the flux through artificial lipophilic membrane from drug loaded below and above their amorphous solubility threshold was investigated.

Login
In Situ Fiber Optic Dissolution Monitoring of Combination Drug Product Containing Three Actives In Situ Fiber Optic Dissolution Monitoring of Combination Drug Product Containing Three Actives

This study introduces a developed computational method for real time concentration measurements of multiple APIs using in situ fiber optic UV-Vis monitoring.

Login
Using Biorelevant Flux Measurements for Prediction of Fraction Absorbed for the Drug Products of Poorly Soluble Compounds Using Biorelevant Flux Measurements for Prediction of Fraction Absorbed for the Drug Products of Poorly Soluble Compounds

This study demonstrated a feasibility of using flux measurements through gastro-intestinal tract (GIT) mimicking artificial membrane to predict MAD and Fa values in biopharmaceutics modelling for BCS Class 2 drugs.

Login
Close