Resource Library

The UV imaging and MATLAB data analysis setup constituted a significant technical development in terms of visualizing behavior for injectable formulations intended for intra-tumoral delivery, and, thereby, a step toward the establishment of a bio-predictive in vitro release-testing method.

This webinar will describe how Pion’s instruments are providing effective dissolution studies and risk analyses during GSK’s drug development pipeline, and how you can also leverage these technologies in your drug formulation R&D approaches.

The goal of the work done here was the preparation and advanced characterization of 3D printed orodispersible tablets (ODTs) containing fluconazole, printed by the fused deposition modeling (FDM) method.

Using Pion's SDi2 surface dissolution imaging system to evaluate the erosion and swelling behavior of the tablets with hydrophilic matrices, or hard galantine capsules filled with solid dispersions.

This article describes the use of Pion's inForm platform to simulate the transition in the gastrointestinal tract and the permeation to the biological membranes. This is a collaboration between Pion Inc. and the University of Barcelona.

SEDDS formulations consist of complex mixtures of lipid-surfactant agents in order to match the target interfacial tension.  The absorption rate of the Active Pharmaceutical Ingredient (API) can be enhanced by fine tuning the composition of SEDDS.

Zentiva is a generics manufacturer that is developing innovative processes to manufacture APIs, and to formulate the drug product itself.  It is using Pion instruments to better understand the API molecule’s behavior in-vivo and any potential risks to progression are critical in the development of new generic medicines.

This webinar describes the development pathway Pion has taken when developing the ECM XR, an artificial extracellular matrix for use in extended-release studies within SCISSOR.

DissoPro 3.6 is now available with improved functionality to make administrative duties simpler, security setup more straight forward and data analysis more capable and flexible. Please see the release note for more detailed information.

PAMPA is a high-throughput platform for assessing drug permeability using artificial membranes that mimic drug uptake under gastro-intestinal conditions (GIT), across the blood-brain barrier (BBB) or through the human skin. It provides robust, reliable, and relevant results that support preformulation screening, and for the evaluation/comparison of complex formulations.

Generally, some weakly basic insoluble drugs will undergo precipitate and redissolution after emptying from the stomach to the small intestinal, resulting in the limited ability to predict the absorption characteristics of compounds in advance. Absorption is determined by the solubility and permeability of compounds, which are related to physicochemical properties, while knowledge about the absorption of redissolved precipitate is poorly documented. Considering that biorelevant media have been widely used to simulate gastrointestinal fluids, sufficient precipitates can be obtained in biorelevant media in vitro.