Resource Library

The development of subcutaneous (SC) formulations presents particular challenges, especially in understanding SC behavior in vivo. Technology that can help formulators understand how a drug product will behave as it enters the human SC space is vital and will pave the way for faster, more effective SC formulations, leading to more SC products reaching clinical trials and ultimately the market.

In PAMPA, the Gut-Box provides stirring that matches the hydrodynamics in the gastrointestinal tract (GIT). It also provides an additional order of permeability response for more accurate overall results for the GIT and the blood brain barrier

View this on-demand webinar and learn how PrepEngine can help you simplify and accelerate the sample preparation process. The result is a compact benchtop design that prepares samples up to 90% faster than conventional methods with a stable, consistent process that eliminates the need for re-testing.

Enteric polymers are widely used in amorphous solid dispersion (ASD) formulations. The aim of the current study was to explore ASD failure mechanisms across a wide range of pH conditions that mimic in vivo gastric compartment variations where enteric polymers such as hydroxypropyl methylcellulose phthalate (HPMCP) and hydroxypropyl methylcellulose acetate succinate (HPMCAS) are largely insoluble.

In this study, the stability and intrinsic dissolution of vacuum compression molded (VCM) amorphous solid dispersions (ASDs) of efavirenz (EFV) were investigated in relation to its solubility limits in seven polymers determined by the melting point depression (MPD) method.

In this paper, we have determined the acidity constants (pKa) of nine flavonoids spectrophotometrically – and for the first time, two new pKas have been determined for Apigerin and a new one for Fisetin.

Designed specifically for laboratory use, the LabEye is a ready-to-implement multi-camera system performing visual process monitoring, chronicling research in HD clarity and providing automation troubleshooting.

PrepEngine is a Flexible Life Science Processing Platform that can Extract Materials into Solution, Mix, Centrifuge, Lyse and more. 

PrepEngine is Modular and is ready to add automation and control to your process. With modules for extraction, mixing, centrifugation, lysing, and more, you’ll be able to overcome your toughest challenges.

Evaluate the absorption potential of your drug compounds. Bridging the gap between in vitro experiments and in vivo outcomes.

Formulation and drug delivery technology play an important role in oral drug product development.