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Pion experts keep you informed with precise, accessible resources on a range of topics. Browse below to see how to optimize your equipment and research methods. Alternatively filter by your interest area. In addition we are delighted to bring you published resources from reliable and relevant experts. Browse below for articles and features recommended by Pion or filter your search for specific applications, products, or formats.

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Enabling SEDDS Formulation Choice through In Vitro-In Vivo Correlation with BASF and Pion Enabling SEDDS Formulation Choice through In Vitro-In Vivo Correlation with BASF and Pion

SEDDS formulations consist of complex mixtures of lipid-surfactant agents in order to match the target interfacial tension.  The absorption rate of the Active Pharmaceutical Ingredient (API) can be enhanced by fine tuning the composition of SEDDS.

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Lessons-learned Advanced in vitro methods in generic drug product development

Zentiva is a generics manufacturer that is developing innovative processes to manufacture APIs, and to formulate the drug product itself.  It is using Pion instruments to better understand the API molecule’s behavior in-vivo and any potential risks to progression are critical in the development of new generic medicines.

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"Exciting new development for our SCISSOR - ECM XR artificial extracellular matrix for extended-release studies" "Exciting new development for our SCISSOR - ECM XR artificial extracellular matrix for extended-release studies"

This webinar describes the development pathway Pion has taken when developing the ECM XR, an artificial extracellular matrix for use in extended-release studies within SCISSOR.

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Parallel Artificial Membrane Permeability Assay  (PAMPA) Platform - Product Sheet Parallel Artificial Membrane Permeability Assay (PAMPA) Platform - Product Sheet

PAMPA is a high-throughput platform for assessing drug permeability using artificial membranes that mimic drug uptake under gastro-intestinal conditions (GIT), across the blood-brain barrier (BBB) or through the human skin. It provides robust, reliable, and relevant results that support preformulation screening, and for the evaluation/comparison of complex formulations.

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Characterizing the Physicochemical Properties of Two Weakly Basic Drugs and the Precipitates Obtained from Biorelevant Media Characterizing the Physicochemical Properties of Two Weakly Basic Drugs and the Precipitates Obtained from Biorelevant Media

Generally, some weakly basic insoluble drugs will undergo precipitate and redissolution after emptying from the stomach to the small intestinal, resulting in the limited ability to predict the absorption characteristics of compounds in advance. Absorption is determined by the solubility and permeability of compounds, which are related to physicochemical properties, while knowledge about the absorption of redissolved precipitate is poorly documented. Considering that biorelevant media have been widely used to simulate gastrointestinal fluids, sufficient precipitates can be obtained in biorelevant media in vitro.

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Best Practices for PhysChem determination using Pion SiriusT3 Best Practices for PhysChem determination using Pion SiriusT3

Pion has provided support to Pion SiriusT3 end-users for many years. We have collected key notes to make sure that users obtain accurate results and to provide expert advice to best design successful analysis learning from the information already provided from previous analysis.

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Best practices in Fiber Optic Dissolution Testing Best practices in Fiber Optic Dissolution Testing

How to obtain richer data before clinical trials, with well designed fiber optic dissolution experiments

Are you looking for a way to correctly and accurately measure dissolution in real time as part of your early stage formulation studies? Attend this webinar to learn how to perform fiber optic in vitro dissolution testing to gain insights that are usually only available in vivo.

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SCISSOR N3 Product Sheet SCISSOR N3 Product Sheet

The SCISSOR N3 advances the Pion SubCutaneous Injection Site Simulator in vitro model capability for investigating the release performance of subcutaneous formulations under simulated physiological conditions. It assesses the risk and performance of subcutaneously administered drugs including biologics, peptides and small molecule.

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Scissor Demo Scissor Demo

Watch a 10 minute video of the Pion SCISSOR, the first instrument designed specifically to assess the risk and performance of subcutaneously administered drugs including biologics, peptides and small molecules. It generates the same rank orders of bioavailability observed in humans.

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MacroFLUX Demo MacroFLUX Demo

In many cases, dissolution experiments alone cannot predict the in vivo response to drug products due to the complicated interplay of solubility and permeability in complex media. By introducing a stirred absorption chamber into familiar USP dissolution apparatus, Pion’s MacroFLUX™ allows you to extend the utility of in situ UV concentration monitoring to provide an accurate assessment of transmembrane FLUX. Watch this short video to learn more!

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