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Pion experts keep you informed with precise, accessible resources on a range of topics. Browse below to see how to optimize your equipment and research methods. Alternatively filter by your interest area. In addition we are delighted to bring you published resources from reliable and relevant experts. Browse below for articles and features recommended by Pion or filter your search for specific applications, products, or formats.

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Release notes - DissoPro 3.5 Release notes - DissoPro 3.5

DissoPro 3.5 is now available with improved functionality to make administrative duties simpler, security setup more straight forward and data analysis more capable and flexible. Please see the release note for more detailed information.

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Pion Mini DT NEW Pion MiniDT- Pion’s Mini Dissolution Tester

Small volume dissolution testing has been an integral part of the global drug development process for decade. Now, with the launch of the Pion MiniDT, the industry now has a dedicated platform to perform this type of testing.
Designed with simplicity in mind, this ultra-low footprint instrument will allow the use of standard U.S. 100 and 200 mL vessels as well as the 250 mL China style mini-vessel.

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A video introduction into MicroDISS Profiler™ instrument and its applications A video introduction into MicroDISS Profiler™ instrument and its applications

An overview of Pions flagship product, the MicroDiss Profiler incorporating the Rainbow fiber optic system. 

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Probing the mechanism of bupivacaine drug release from multivesicular liposomes Probing the mechanism of bupivacaine drug release from multivesicular liposomes

Researchers from FDA use Pion’s MicroDISS Profiler to probe mechanism of the release kinetics of a drug from multivesicular liposomes

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Degree and Extent of Supersaturation of Amorphous Pharmaceuticals and Their Flux through Lipophilic Membrane Degree and Extent of Supersaturation of Amorphous Pharmaceuticals and Their Flux through Lipophilic Membrane

The goal of this study was to apply in situ concentration monitoring for quick assessment of degree and extent of supersaturation that can be achieved by amorphization of the drug. In addition the comparison of the flux through artificial lipophilic membrane from drug loaded below and above their amorphous solubility threshold was investigated.

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In Situ Fiber Optic Dissolution Monitoring of Combination Drug Product Containing Three Actives In Situ Fiber Optic Dissolution Monitoring of Combination Drug Product Containing Three Actives

This study introduces a developed computational method for real time concentration measurements of multiple APIs using in situ fiber optic UV-Vis monitoring.

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Using Biorelevant Flux Measurements for Prediction of Fraction Absorbed for the Drug Products of Poorly Soluble Compounds Using Biorelevant Flux Measurements for Prediction of Fraction Absorbed for the Drug Products of Poorly Soluble Compounds

This study demonstrated a feasibility of using flux measurements through gastro-intestinal tract (GIT) mimicking artificial membrane to predict MAD and Fa values in biopharmaceutics modelling for BCS Class 2 drugs.

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Simultaneous in situ monitoring of free drug concentration and nanoparticles during dissolution testing of nanocrystalline and amorphous formulations Simultaneous in situ monitoring of free drug concentration and nanoparticles during dissolution testing of nanocrystalline and amorphous formulations

The goal of this study was to develop a method of de-convoluting the UV-Vis spectra measured in situ to not only obtain the concentration of free drug in the presence of light absorbing nanoparticles but also to quantify the
concentration of nanoparticles present in suspensions.interplay between dissolution, solubility and permeability

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From Traditional Dissolution to  In Vivo Predictive Flux Measurements From Traditional Dissolution to In Vivo Predictive Flux Measurements

The webinar introduces the use of in situ fiber optic technique for traditional dissolution monitoring as well as for in vivo predictive flux measurements that uncover the interplay between dissolution, solubility and permeability

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Prediction of Bioequivalence and Food Effect Using Flux- and Solubility-Based Methods Prediction of Bioequivalence and Food Effect Using Flux- and Solubility-Based Methods

Flux values could be ised as input parameters for biopharmaceutics modeling and simulations to estimate ford effect and bioequivalence. 

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