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Degree and Extent of Supersaturation of Amorphous Pharmaceuticals and Their Flux through Lipophilic Membrane Degree and Extent of Supersaturation of Amorphous Pharmaceuticals and Their Flux through Lipophilic Membrane

The goal of this study was to apply in situ concentration monitoring for quick assessment of degree and extent of supersaturation that can be achieved by amorphization of the drug. In addition the comparison of the flux through artificial lipophilic membrane from drug loaded below and above their amorphous solubility threshold was investigated.

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In Situ Fiber Optic Dissolution Monitoring of Combination Drug Product Containing Three Actives In Situ Fiber Optic Dissolution Monitoring of Combination Drug Product Containing Three Actives

This study introduces a developed computational method for real time concentration measurements of multiple APIs using in situ fiber optic UV-Vis monitoring.

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Using Biorelevant Flux Measurements for Prediction of Fraction Absorbed for the Drug Products of Poorly Soluble Compounds Using Biorelevant Flux Measurements for Prediction of Fraction Absorbed for the Drug Products of Poorly Soluble Compounds

This study demonstrated a feasibility of using flux measurements through gastro-intestinal tract (GIT) mimicking artificial membrane to predict MAD and Fa values in biopharmaceutics modelling for BCS Class 2 drugs.

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Simultaneous in situ monitoring of free drug concentration and nanoparticles during dissolution testing of nanocrystalline and amorphous formulations Simultaneous in situ monitoring of free drug concentration and nanoparticles during dissolution testing of nanocrystalline and amorphous formulations

The goal of this study was to develop a method of de-convoluting the UV-Vis spectra measured in situ to not only obtain the concentration of free drug in the presence of light absorbing nanoparticles but also to quantify the
concentration of nanoparticles present in suspensions.interplay between dissolution, solubility and permeability

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From Traditional Dissolution to  In Vivo Predictive Flux Measurements From Traditional Dissolution to In Vivo Predictive Flux Measurements

The webinar introduces the use of in situ fiber optic technique for traditional dissolution monitoring as well as for in vivo predictive flux measurements that uncover the interplay between dissolution, solubility and permeability

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Prediction of Bioequivalence and Food Effect Using Flux- and Solubility-Based Methods Prediction of Bioequivalence and Food Effect Using Flux- and Solubility-Based Methods

Flux values could be ised as input parameters for biopharmaceutics modeling and simulations to estimate ford effect and bioequivalence. 

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Simultaneous Determination of Intrinsic Solubility Simultaneous Determination of Intrinsic Solubility and pK of Ionizable Pharmaceutical Compounds Simultaneous Determination of Intrinsic Solubility Simultaneous Determination of Intrinsic Solubility and pK of Ionizable Pharmaceutical Compounds

Simultaneous Determination of Intrinsic Solubility Simultaneous Determination of Intrinsic Solubility and pK of Ionizable Pharmaceutical Compounds Simultaneous Determination of Intrinsic Solubility and pK a of Ionizable Pharmaceutical Compounds a of Ionizable Pharmaceutical Compounds using UV Titrations

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Spectrophotometric pKa Determination of Ionizable Pharmaceuticals: Resolution of Molecules with Weak pH-Dependent Spectral Shift Spectrophotometric pKa Determination of Ionizable Pharmaceuticals: Resolution of Molecules with Weak pH-Dependent Spectral Shift

Spectrophotometric pKa Determination of Ionizable Pharmaceuticals: Resolution of Molecules with Weak pH-Dependent Spectral Shift

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Design and development of a novel diffusion cell for advanced UV imaging to characterise pharmaceutical formulations Design and development of a novel diffusion cell for advanced UV imaging to characterise pharmaceutical formulations

Permeation tests are conducted to study API release from semisolid formulations to predictin vivo performance. United States Pharmacopeia details the Franz cell diffusion based evaluation of a topical formulation In this method, a topical formulation is administered into a donor chamber and permeation or diffusion is evaluated by quantifying the concentration of the drug in the receptor chamber. 

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Multi-lab intrinsic solubility measurement reproducibility in CheqSol and shake-flask methods Multi-lab intrinsic solubility measurement reproducibility in CheqSol and shake-flask methods

 

This commentary compares 233 CheqSol intrinsic solubility values (log S0) reported in the Wiki-pS0 
database for 145 different druglike  molecules  to  the 838 log S0 values determined  mostly  by  
the  saturation  shake- flask (SSF) method for 124 of the molecules  from the CheqSol set. The 
range of log S0 spans from  -1.0 to g molar units), averaging at -3.8.                              
                                                          

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