Resource Library

AuPRO™ is Pion’s UV absorption data collection and refinement software for the Rainbow dynamic dissolution monitor
that offers a broad range of advanced tools for today’s R&D scientists to analyze dissolution, solubility, and flux data
or measure UV-absorption-based concentration in any assay setup.

If you work on subcutaneous formulation development, then you will be interested to learn how the SCISSOR N3 system overcomes the traditional challenges with formulation and development. 

The skin permeation, Kp, of a chemical compound is a relevant parameter in fields such as toxicology, exposure to pollutants, or dermal studies of pharmaceutical and cosmetic interest. Nonetheless, its experimental determination is not a trivial task, and for this reason alternative methods to estimate Kp have been developed.

This work confirms the potential of the PAMPA model as a tool to discriminate between different vehicles for permeation of actives. In addition, a positive correlation between the skin PAMPA model and the Franz cell studies using porcine skin and human skin was observed for the cumulative amount of PE permeated.

This technical note intends to help current users of Pion’s fiber optic systems to perform quality verification and automated refinement of data collected during experiments employing in situ concentration monitoring methods.

Fiber optic dissolution testing offers a fast and cost-effective method for determining a drug product's release rate over time. With 21 years of industry leadership, Pion’s fiber optic technology delivers benchmark performance and reliability.

From small scale R&D to large scale manufacturing equipment, BEE homogenizers provide unparalleled fluid processing capabilities for particle size reduction, cell disruption, and creating stable nanoemulsions & dispersions.

Learn how BEE International's high pressure homogenizers can benefit your pharmaceutical products.

The development of subcutaneous (SC) formulations presents particular challenges, especially in understanding SC behavior in vivo. Technology that can help formulators understand how a drug product will behave as it enters the human SC space is vital and will pave the way for faster, more effective SC formulations, leading to more SC products reaching clinical trials and ultimately the market.

In PAMPA, the Gut-Box provides stirring that matches the hydrodynamics in the gastrointestinal tract (GIT). It also provides an additional order of permeability response for more accurate overall results for the GIT and the blood brain barrier