Application/Technical Notes

 

FLUX


This technical note introduces devices that can be utilized for flux measurements in a systematic and reproducible manner. The small volume apparatus called μFLUX is compatible with Pion’s mini-bath (MB-8) and can be used on various stages of formulation development when amount of API and/or its formulations is limited while many permutations of different formulation strategies have to be investigated. The other device MacroFLUX is an absorption chamber insert into USP 1 or 2 dissolution bath vessels. Both apparati would allow assessment of complex interplay between solubility, permeability and dissolution rate in formulation development and would provide valuable tools for in vivo predictive in vitro studies.