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|WEBINAR: Interesting results from our Analytical Services department|
Our analytical services department run samples for scores of important customers every year. Whilst we obviously cannot share customer confidential information, some customers have kindly given us permission to share some of the more interesting results we observed using their compounds.
|WEBINAR: In vitro measurement of drug bioavailability following subcutaneous injection|
Subcutaneous injection is a popular route of administration for non-oral drugs such as biotherapeutics. Historically, there has been no in vitro test to evaluate performance of subcutaneous formulations. Invented by an academic pioneer in the field, the Pion Scissor addresses this gap.
|WEBINAR: Log P- History, Measurement and Applications in Drug Development|
Log P is one of the most important and useful properties that drug researchers can measure. In this fascinating webinar, we explore the history of Log P, and describe its use in today’s pharmaceutical industry
|WEBINAR: Accessing hydrogen bond parameters and their application in drug discovery|
Hydrogen bonding plays a key role in in vivo drug behavior: For example how APIs can interact with and permeate membranes. In this webinar, a leader in the field, Giulia Caron of the University of Turin, joins us to describe methods for observing hydrogen bonding effects.
|WEBINAR: Understanding and Measuring pKa|
This is our first pKa webinar. In it, we describe the origins of the measurement, the origins of the science we use for our measurement platform and show you some of the extremely accurate data generated by the Pion SiriusT3
|WEBINAR: How pKa Values are used in the Pharmaceutical Industry|
We have previously shown you how we measure pKa. This follow on webinar will describe why pKa is considered such a critical measurement in drug discovery and development environments.
|WEBINAR: State of the art UV methods for measuring pKa|
Pion have long been the leader in pKa measurement. We have several techniques perfected, but the most popular of these with both our in-house chemists and our customers are those methods based on UV spectrophotometry. These methods are fast, compound sparing, and extremely accurate. This webinar explains the scientific principles behind UV metric pKa measurement.
|pKa and physchem property measurements for the pharmaceutical industry|
pKa is a core competence of Pion, and we have many methods for measuring it. This webinar explains the concepts of pKa measurement, the experimental means of measuring it, and the key role that this property plays in the behavior of drugs.
|WEBINAR: In-vitro approaches for investigating intestinal precipitation of oral drugs|
A known issue in drug formulation is the tendency of certain drugs, particularly weak bases, to dissolve initially in the gastric environment and then re-precipitate in the intestine. This webinar describes several in vitro strategies for stimulating, measuring and mitigating this effect.
|The behaviour of drug formulations under biorelevant and biphasic conditions|
One of the key challenges for formulators is making in vitro experiments relevant to in vivo outcomes. Among the strategies for obtaining this data are the use of biphasic dissolution experiments in order to get measures of aqueous dissolution and permeability in parallel, and also the use of biorelevant media such as FaSSGF, FaSSIF and FeSSIF to more accurately simulate the dissolution environment within the human body. This webinar explores real-world use of some of these techniques.
|WEBINAR: Investigating Supersaturation and Solubility Enhancement|
This webinar describes some methods for investigating compounds’ tendency to supersaturate, and the use of various excipients such as crystallization inhibitors to exploit this tendency and therefore enhance and/or prolong solubility
|WEBINAR: How Cheqsol Works|
There are several effective ways to measure solubility, with most leading to an equilibrium solubility endpoint. Pion’s patented CheqSol™ method is a sophisticated assay allowing the observation of all intermediate solubility steps, such as supersaturated, metastable states.
|WEBINAR: Physicochemical Properties and their relation to ADMET|
This is one of our most popular webinars. Joined by our very good customer Cyprotex, we explore why understanding physchem properties is vital when it comes to understanding the ADMET behaviors of APIs
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|WEBINAR: Measuring solubility – what’s best for you?|
There are multiple traditional, miniaturized and innovative techniques for measuring solubility. Depending upon throughput, purpose, and richness of experimental data required, any of these techniques may be appropriate. This webinar explores some different options in the hope of guiding you towards the best method for achieving your goals.
|WEBINAR: Pion inForm – a new instrument for investigating solubility and dissolution|
This webinar describes the Pion inForm and the various Biorelevant assays which it can run, such as Biorelevant dissolution, controlled supersaturation and GI lipolysis.
|PODCAST: Precipitation Behaviour of Weakly Basic Compounds – Solubility and Dissolution Enhancement|
This podcast was recorded as a result of an especially well received presentation given by then-CSO John Comer. A great many small molecule drugs are weakly basic, leading to known pluses such as supersaturation potential and known issues such as intestinal precipitation. This podcast explores some of these effects using real APIs.