See what you’re missing!
Have you ever wanted to visualize the dissolution characteristics of a dosage forms more closely than with the naked eye?
Are you struggling with an investigation that you think might be tied to a mechanical or physical property of the dosage?
Would the ability to have more insight into the dissolution at the surface of the dosage allow you to design and formulate more intelligently?
In this time lapse video, the SDI2 is being used to assess the performance of an enteric coating on a diclofenac dosage. The system will simultaneously measure a UV wavelength for concentration and a visible wavelength for physical phenomena. Using the SDi2 dual pump configuration, you can accomplish a media change assay ensuring no release in an acid phase and complete disintegration and solubilization in the buffer.
The Pion SDi2 is designed specifically to accelerate your pre-formulation and formulation development. The next generation of UV imaging from Pion, the SDi2 is used for investigating physical processes occurring at the solid-liquid interface during dissolution. As well as measuring intrinsic dissolution and release rates of drug products, the SDi2 is ideal for quantifying swelling, erosion and disintegration kinetics of a range of whole dosage forms. The SDi2 uses a powerful 4.2 megapixel ActiPixTM detector to record ultraviolet and visible light intensity data in real-time and in two dimensions. It produces high resolution videos that record dynamic processes as they happen. The SDi2 uses a fully integrated fluidics system with a choice of two different flow cells to cover a broad range of applications and sample types.
Compact Flow Cell
Compact flow cell with direction of dissolution medium flow
- Designed around the original Nelson and Shah flow cell for dissolution under laminar flow (Nelson, K. G.; Shah, A. C., J Pharm Sci 1975, 64 (4), 610-4).
- Small volume cell uses minimal sample amount, ideal for research or early development
Measure IDR (intrinsic dissolution rate) of API
IDR experiments using compact flow cell. 3 mg compact of theophylline in simulated gastric fluid flowing at 0.8 mL/min. Absorbance data of theophylline in solution at A) 280 nm and B) 255 nm, obtained from a single experiment.
Whole Dosage Flow Cell
Whole dosage flow cell with capsule, showing direction of dissolution medium flow
- Designed around well-established USP apparatus 4 cell (flow-through dissolution)
- A unique insight into mechanistic detail whilst using familiar, widely accepted dissolution apparatus
Measure rate of swelling for extended release dosage forms
Obscuration images of an extended release dosage form in a pH shift experiment from gastric to intestinal pH, using 520 nm LED at 1) t=0 and 2) t=6 hours. Width of tablet can be measured from experimental onset.
Measure erosion & drug release from whole dosage forms
UV absorbance images of 3D printed Warfarin & Eudragit tablet in 0.1 M HCl at A) t=1 and B) t=60 minutes at 255 nm. Tablet size reduces, while drug concentration in solution increases, indicated by dark blue to light blue false colour change in dissolution medium. FDM 3D printed tablets produced by Dr. Basel Arafat and Dr. Mohammed AlbedAlhnan , The School of Pharmacy and Biomedical Sciences, UCLAN, Preston, UK.