Biorelevant Dissolution

Overview

Fiber optic dissolution is the cost effective, quicker, more reliable alternative for extended, controlled or modified release dissolution.

With over 18 years on the market, Pion’s fiber optic technology is the benchmark of performance and reliability. Fifteen out of fifteen of the top pharmaceutical companies use Pion’s fiber optic technology for their in-situ UV monitoring needs. Pion’s fiber optic technology is a flexible and reliable tool for determining the rate of release of a drug substance over time. (Reference: Fiber optics in the USP <1092>). Pion offers powerful instrumentation for biorelevant dissolution and solubility analysis of formulations and dosage forms.

μDISS Profiler™

Are you disappointed with current methods for dissolution analysis?
The µDISS Profiler™ is an in situ fiber optic UV monitoring system with real time data display from parallel measurement cells.

Mini-Bath (MB8)

Are you concerned that reliance on large volume disso is inhibiting the speed of drug development?
The Mini-Bath is a robust and versatile platform designed specifically for small volume, parallel dissolution experiments.

inForm

Are you frustrated by the lack of options for accurately predicting in vivo Bioavailability using in vitro tools?
The Pion inForm is a powerful instrument for bio-relevant dissolution and solubility analysis of formulations and dosage forms.

Contract Research

Do you need a CRO who is the leader in their field?
Pion’s analytical services are provided by highly experienced scientists who specialize in physicochemical and physical analysis. Our Gold Standard assay and investigative study reports provide expert interpretation to give essential context to the work performed.

Biorelevant Dissolution

Resources

Image	Title
	Controlled supersaturation by the solvent quench method, with UV monitoring of precipitation
	A DoE study to understand partition rate in a biphasic system
	AAPS Understanding drug release mechanisms of metformin using complementary in vitro dissolution tools
	Biphasic dissolution studies: Impact of concentration and particle size on partition rate
	Validation of the SDi2 intrinsic dissolution rate measurement
	Understanding drug release mechanisms from diclofenac tablets using the SDi2
	AN404 Biorelevant dissolution with gradient pH adjustment
	Impact of Biorelevant Media on Apparent Solubility and Biopharmaceutical Classification of Poorly Soluble Compounds
	Dissolution Rate and Apparent Solubility of Poorly Soluble Compounds in Biorelevant Fluids
	Dissolution-Permeability Apparatus with Integrated In Situ Concentration Monitoring of both Donor and Receiver Compartments

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