Fiber optic dissolution is the quicker, more reliable alternative for large or difficult data sets.
Traditional dissolution is aimed primarily at post-market QC environments. Experiments take place in extremely large vessels (typically 900mL) which, whilst being entirely appropriate for the intended applications, can be a limitation when it comes to applications such as formulation development where fast measurements are required using much smaller amounts of API or formulated API.
Furthermore, there are increasing internal and regulatory drivers for companies to generate more biorelevant data – for example by using biomimetic media, measuring absorption as well as dissolution and gathering data along a gradient pH in order to mimic a drug’s transtition through the stomach and GI tract.
Pion has developed extremely powerful techniques for scientists working in discovery, preformulation and formulation which operate using small amounts of sample, and offer numerous proprietary assay types developed specifically for users like you.